Live Monitor utilizes WCF service. Due to WCF services behavior additional configuration may be required on sites with multiple bindings (for example http://mysite.com and http://www.mysite.com).
If your site is running on ASP.NET 4 or later you can enable multiple site bindings by setting attribute multipleSiteBindingsEnabled="true" of serviceHostingEnvironment section. This configuration setting is a requirement if you want to run CMO Live Monitor on multiple sites in an EPiServer Enterprise setup with multiple bindings.
<configuration> <system.serviceModel> <serviceHostingEnvironment multipleSiteBindingsEnabled="true" .../> </system.serviceModel> </configuration>